EMA401: an old antagonist of the AT2R for a new indication in neuropathic pain
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چکیده
منابع مشابه
EMA401: an old antagonist of the AT2R for a new indication in neuropathic pain
EMA401 is an old molecule, synthesized by Parke-Davis in the last century and characterized at that time as an AT2R antagonist. Professor Maree Smith and her group from the University of Queensland (Australia) patented the drug and many related derivatives and other compounds with high affinity for the AT2R for the indication neuropathic pain in 2004, an example of drug repositioning. After som...
متن کاملMechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies
BACKGROUND The clinical efficacy of the Angiotensin II (AngII) receptor AT2R antagonist EMA401, a novel peripherally-restricted analgesic, was reported recently in post-herpetic neuralgia. While previous studies have shown that AT2R is expressed by nociceptors in human DRG (hDRG), and that EMA401 inhibits capsaicin responses in cultured hDRG neurons, the expression and levels of its endogenous ...
متن کاملPharmacotherapy for Neuropathic Pain: The Old and the New
Dr McCarberg is Assistant Clinical Professor (voluntary), University of California School of Medicine, Boarded in Family Medicine, Geriatrics, and Pain Medicine, Family Medicine Kaiser Permanente, San Diego, California. Conflict of Interest: The author reports serving on the speaker’s bureau for Eli Lilly, Endo, Forest, Janssen, Ligand, Organon, Ortho-McNeil, Pfizer Inc, PriCara, and Purdue. Of...
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ژورنال
عنوان ژورنال: Journal of Pain Research
سال: 2017
ISSN: 1178-7090
DOI: 10.2147/jpr.s128520